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Safety of Slow-Pulsed Transcranial Electrical Stimulation in Acute Spike Suppression

December 6, 2019

Ann Clin Transl Neurol. 2019 Dec;6(12):2579-2585. doi: 10.1002/acn3.50934. Epub 2019 Nov 11.
Holmes MD1Feng R2Wise MV1Ma C2Ramon C1,3Wu J2Luu P4Hou J5Pan L2Tucker DM4.


We examined the effects of slow-pulsed transcranial electrical stimulation (TES) in suppressing epileptiform discharges in seven adults with refractory epilepsy. An MRI-based realistic head model was constructed for each subject and co-registered with 256-channel dense EEG (dEEG). Interictal spikes were localized, and TES targeted the cortical source of each subject's principal spike population. Targeted spikes were suppressed in five subject's (29/35 treatment days overall), and nontargeted spikes were suppressed in four subjects. Epileptiform activity did not worsen. This study suggests that this protocol, designed to induce long-term depression (LTD), is safe and effective in acute suppression of interictal epileptiform discharges.

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