Simon S. Lo M.D.

 Simon  S. Lo M.D.

Specialties and Expertise

Brain tumors, Gamma knife, Radiation oncology, Spine tumors


Cancer Care




Gamma Knife Center at Harborview

325 9th Ave., Center Tower, Ground Floor, GCT 44
Seattle, WA 98104
Phone: 206.744.8067|Map It 

Radiation Oncology Services at UWMC

1959 NE Pacific St., 1st Floor, NN 106
Seattle, WA 98195
Phone: 206.598.4100|Map It 

Alvord Brain Tumor Center at UWMC

1959 NE Pacific St., 7th Floor, Pacific Tower
Seattle, WA 98195
Phone: 206.598.2282|Map It 


Dr. Lo is an internationally renowned radiation oncology expert in brain and spine tumors, stereotactic radiosurgery and stereotactic body radiotherapy.

Dr. Lo takes care of patients with brain and spine tumors, oligometastases, and some benign conditions requiring Gamma Knife stereotactic radiosurgery e.g. trigeminal neuralgia and arteriovenous malformations. He is currently a Professor of Radiation Oncology and Vice Chair for Strategic Planning at UW Department of Radiation Oncology.

Dr. Lo earned his medical degree from the Faculty of Medicine, The Chinese University of Hong Kong. He completed a residency in Clinical Oncology under the Fellowship of Royal College of Radiologists, UK curriculum at Queen Elizabeth Hospital, Hong Kong before performing a second residency in Radiation Oncology at University of Minnesota and an American College of Radiation Oncology Fellowship in Gastrointestinal Radiation Oncology at Mayo Clinic, MN. He is certified for Gamma Knife stereotactic radiosurgery.

Dr. Lo was previously the Director of Neurologic Radiation Oncology and Radiosurgery Services at University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center as well as Professor of Radiation Oncology at Case Western Reserve University in Cleveland, OH. He was one of the co-leaders in building the Spinal Cord Compression Pathway at University Hospitals Seidman Cancer Center. Prior to that, he was the Associate Professor of Radiation Oncology, Residency Program Director and Neurological Surgery and the Director of Neuro-Radiation Oncology and Stereotactic Body Radiotherapy at Arthur G. James Cancer Hospital, The Ohio State University. He was instrumental in building one of the first two stereotactic body radiotherapy programs in the state of Ohio from the ground up when he was at The Ohio State University.

Dr. Lo is board certified in American Board of Radiology (ABR) and is also an examiner for ABR in central nervous system/ pediatric tumors. He is a member of the Cancer Prevention and Control Committee and a liaison to the Lung Cancer Committee and Functional Imaging work group with NRG Oncology, one of the nation’s largest cancer trial groups. He is also the Radiation Oncology Track Co-Chair for the refresher courses for Radiological Society of North America, one of the largest medical organizations in the world. He has been inducted as a Fellow of American College of Radiology (FACR) and is currently the President-elect for the Council of Affiliated Regional Radiation Oncology Societies, the radiation oncology chapter of the American College of Radiology (ACR). He is the co-lead for the international consortia for stereotactic body radiotherapy for renal cell carcinoma and head and neck cancer, respectively and has participated in or led international/ national practice guidelines in brain, bone and spinal metastases as well as stereotactic body radiotherapy for lung cancer (American Society for Radiation Oncology and American College of Radiology). He has been invited as a panel member to serve on the American Academy of Neurological Surgeons (AANS)/ Congress of Neurological Surgeons (CNS) Taskforce in Brain Metastases to help develop multiple evidence cased practice guidelines for brain metastases. Dr. Lo is the lead editor for 3 textbooks with one dedicated to stereotactic body radiotherapy for spinal metastasis and a co-editor of a 4th textbook dedicated to brain and spine radiosurgery. He has given numerous lectures or training courses in prestigious meetings/ conferences in the US, Canada, Europe and Asia and numerous prestigious universities in the US, Canada, Germany and Asia.

Patient Care Philosophy

At the UW Department of Radiation Oncology, we bring together all aspects of brain and spine tumor evaluation and treatment for the patient's benefit. Utilizing the most advanced radiation technologies, we aim for the best outcomes.

As a physician, nothing is more fulfilling than seeing the positive impact my care makes to my patients. I feel that it is a privilege for me to be able to look after patients. I always encourage patients to be actively engaged in their care.

Personal Interests

Spending time with family, traveling, hiking, listening to music.

Clinical Interests

Clinical research in brain and spinal tumors; stereotactic radiosurgery and stereotactic body radiotherapy; oligometastasis; brain and spinal metastases.

Research Interests

Research in brain and spinal tumors; stereotactic radiosurgery and stereotactic body radiotherapy; oligometastasis; brain and spinal metastases radiobiological modeling for ablative radiotherapy; toxicities from ablative radiotherapy; international/ national practice guidelines in brain and spinal metastases and stereotactic body radiotherapy.


University of Minnesota Medical SchoolResidencyRadiation Oncology2001
Queen Elizabeth HospitalResidencyOncology1997
Kwong Wah HospitalFellowshipOrthopaedics1993
Prince of Wales HospitalInternship1992
The Chinese University of Hong KongMedical Education1991

Board Certifications

American Board of RadiologyRadiation Oncology2001
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